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2004

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer’s disease in aged mice

Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K

Eur J Neurosci 2004;19(10):2826-2838

PMID: 15147316

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2003

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer’s disease-related neurotoxicity: functional potentiation by isomerization and dimerization

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I

J Neurochem 2003;85(6):1521-1538

PMID: 12787071

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A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer’s disease-relevant insults

Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I

Eur J Neurosci 2003;17(6):1150-1158

PMID: 12670303

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Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, Kouyama K, Terashita K, Aiso S, Lin A, Nishimoto I

J Neurochem 2003;84(4):864-877

PMID: 12562529

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2002

Molecular mechanisms for neuronal cell death by Alzheimer’s amyloid precursor protein-relevant insults

Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, Nishimoto I

Neurosignals 2002;11(5):236-250 [Review]

PMID: 12566925

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2001

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer’s amyloid precursor protein with JNK

Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I

J Neurosci 2001;21(17):6597-6607

PMID: 11517249

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A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Aβ

Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I

Proc Natl Acad Sci U S A 2001;98(11):6336-6341 Erratum in: Proc Natl Acad Sci U S A 2001;98(22):12854

PMID: 11371646

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Secreted Aβ does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, Kouyama K, Nishimoto I

Biochem Biophys Res Commun 2001;282(2):548-556

PMID: 11401495

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Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer’s V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner

Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, Nishimoto I

J Neurosci 2001;21(6):1902-1910

PMID: 11245675

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2000

Antibody-regulated neurotoxic function of cell-surface β-amyloid precursor protein

Sudo H, Jiang H, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y, Nishimoto I

Mol Cell Neurosci 2000;16(6):708-723

PMID: 11124892

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1998

Phosphorylation of Sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation

Nishizawa M, Kawasumi M, Fujino M, Toh-e A

Mol Biol Cell 1998;9(9):2393-2405

PMID: 9725902

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