Skip to content

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer’s disease in aged mice

Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K

Eur J Neurosci 2004;19(10):2826-2838

PMID: 15147316

View on PubMed - View PDF


Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer’s disease-related neurotoxicity: functional potentiation by isomerization and dimerization

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I

J Neurochem 2003;85(6):1521-1538

PMID: 12787071

View on PubMed - View PDF

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer’s disease-relevant insults

Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I

Eur J Neurosci 2003;17(6):1150-1158

PMID: 12670303

View on PubMed - View PDF

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, Kouyama K, Terashita K, Aiso S, Lin A, Nishimoto I

J Neurochem 2003;84(4):864-877

PMID: 12562529

View on PubMed - View PDF


Molecular mechanisms for neuronal cell death by Alzheimer’s amyloid precursor protein-relevant insults

Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, Nishimoto I

Neurosignals 2002;11(5):236-250 [Review]

PMID: 12566925

View on PubMed - View PDF


c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer’s amyloid precursor protein with JNK

Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I

J Neurosci 2001;21(17):6597-6607

PMID: 11517249

View on PubMed - View PDF

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Aβ

Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I

Proc Natl Acad Sci U S A 2001;98(11):6336-6341 Erratum in: Proc Natl Acad Sci U S A 2001;98(22):12854

PMID: 11371646

View on PubMed - View PDF

Secreted Aβ does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

Sudo H, Hashimoto Y, Niikura T, Shao Z, Yasukawa T, Ito Y, Yamada M, Hata M, Hiraki T, Kawasumi M, Kouyama K, Nishimoto I

Biochem Biophys Res Commun 2001;282(2):548-556

PMID: 11401495

View on PubMed - View PDF

Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer’s V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner

Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, Nishimoto I

J Neurosci 2001;21(6):1902-1910

PMID: 11245675

View on PubMed - View PDF


Antibody-regulated neurotoxic function of cell-surface β-amyloid precursor protein

Sudo H, Jiang H, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y, Nishimoto I

Mol Cell Neurosci 2000;16(6):708-723

PMID: 11124892

View on PubMed - View PDF


Phosphorylation of Sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation

Nishizawa M, Kawasumi M, Fujino M, Toh-e A

Mol Biol Cell 1998;9(9):2393-2405

PMID: 9725902

View on PubMed - View PDF

Back To Top